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When applying very low cut-off values for patients by using a low pretest probability of sickness, it is crucial to understand that analytical false-good benefits may take place owing to imprecision in the assays at very low concentrations.46
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Another pathobiological mechanism by which intact troponin may be launched through ischaemia with no necrosis could be the formation and release of membranous blebs.70 Blebs are spherical protrusions in the plasma membrane. Their development is driven by boosts in cytoplasmic (intracellular) hydrostatic force.
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